Publications

Selected Publication

    1. B. Akhaphong, A. Lockridge, S. Jo, R.Mohan, JA. Wilcox, RW Cameron, JF Regal and EA. Alejandro. Reduced Uterine Perfusion Pressure Causes Loss of Pancreatic Beta-Cell Area but Normal Function in Fetal Rat Offspring. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, Accepted, October 2018.
    2. B. Hart, E. Morgan and EA. AlejandroNutrient Sensor Signaling Pathways and Cellular Stress in Fetal Growth Restriction. Molecular Endocrinology, Accepted, September, 2018
    3. R.Mohan, D. Baumann and EA. Alejandro. Fetal Undernutrition, placental insufficiency, and pancreatic beta-cell development programming in utero. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, In press, September 2018.
    4. EU. Alejandro, N. Bozadjieva, M. Blandino-Rosano, M. Wasan, L. Elghazi,  S. Vadrevu, S. Satin,  and E. Bernal-Mizrachi.  Overexpression of kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass. Diabetes, May 2017
    5. A. Lockridge, D. Baumann, B. Akhaphong, A. Abrenica, R. Miller and EU. Alejandro. Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis. Islets, Nov 8. 2016
    6. EU. Alejandro, N. Bozadjieva, D. Kumusoglu, S. Abdulhamid, H. Levine, H. Haataja, S. Vadrevu, S. Satin, P. Arvan, and E. Bernal-Mizrachi. Disruption of O-linked N-acetylglucosamine signaling induces ER stress and β-cell failure. Cell Reports, 2015.
    7. EU. Alejandro, B. Gregg, M. Blandino-Rosano, C. Cras-Meneur, and E. Bernal-Mizrachi. Natural History of Beta-cell Adaptation and Failure in Type 2 Diabetes. Mol Aspects Med. 2014 Dec 24. PMID2: 5542976
    8. EU. Alejandro, B. Gregg, T. Wallen, D. Meister, D. Kumusoglu, A. Chen, MJ. Merrins, LS. Satin, M. Liu, P. Arvan, and E. Bernal-Mizrachi. Maternal Diet-induced MicroRNAs and mTOR Underlie Beta-cell Dysfunction in Offspring. Journal of Clinical Investigation, 2014 Sep 2. PMID: 25180600
    9. B. Gregg, L. Elghazi, EU. Alejandro, MR. Smith, M. Blandino-Rosano, D. El-Gabri, C. Cras-Meneur, and E. Bernal-Mizrachi. Exposure of Mouse Embryonic Pancreas to Metformin Enhances the Number of Pancreatic Progenitors. Diabetologia. 2014 Sep 2. PMID: 25249235
    10. M. Blandino-Rosano*, EU. Alejandro*, JO. Scheys, B. Gregg, AY. Chen, L. Rachdi, A. Weiss, D.J. Barker, AP. Gould, L. Elghazi and E. Bernal-Mizrachi. Enhanced Beta-cell Proliferation in Mice Over-expressing a Constitutively Active Form of Akt and One Allele of p21Cip. Diabetologia, 2012. *Co-first Author. PMCID: PMC3646796. *These authors contributed equally to this study.
    11. EU. Alejandro, GE. Lim, AE. Mehran, X, Hu, F. Taghizadeh, D. Pelipeychenko, M. Baccarini, and JD. Johnson. Pancreatic Beta-cell Raf-1 is required for Glucose Tolerance, Insulin Secretion and Insulin 2 Transcription. FASEB J. 2011 Aug 4. PMCID: PMC3205833.
    12. EU. Alejandro, TB. Kalynyak, F. Taghizadeh, KS. Gwiazda, EK. Rawstron, KJ. Jacob and JD. Johnson. Acute Insulin Signaling in Pancreatic Beta-cells Is Mediated by Multiple Raf-1 Dependent Pathways. Endocrinology, 2010 Feb 151(2): 502-12. PMCID: PMC2817610.
    13. KD. Jeffrey, EU. Alejandro, DS. Luciani, TB. Kalynyak, X. Hu, H. Li, Y. Lin, RR. Townsend, KS. Polonsky, and JD. Johnson. Palmitate Targets Carboxypeptidase E to Induce Beta-cell ER-stress and Apoptosis. Proc Natl Acad Sci., 2008 Jun 17;105 (24):8452-7. PMCID: PMC2448857.
    14. EU. Alejandro and JD. Johnson. Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic Beta-cell apoptosis. J Biol Chem. 2008 Jan 25;283(4):2407-17. PMCID: PMC3025401.
    15. M. Maioli*, EU. Alejandro*, G. Tonolo, L.K. Gilliam, L. Bekris, C. S. Hampe, D.A. Obinu, A. Manconi, L. Puddu, K. Lynch, and Åke Lernmark. Epitope-restricted GAD65 autoantibodies among new onset Sardinian Type 2 diabetes patients define phenotypes of autoimmune diabetes. J Clin Endocrinol Metab. 2004 Nov; 89(11):5675-82. *These authors contributed equally to this study. PMID: 15531528.

     


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