Hai-Bin Ruan, PhD

Assistant Professor, Department of Integrative Biology and Physiology (IBP)

Hai-Bin Ruan

Contact Info


Office Phone 612-301-7686

Office Address:
CCRB 3-143

Postdoctoral, Yale University

PhD, Nanjing University, China

BS, Nanjing University, China


Awards & Recognition

  • Visscher Biomedical Scholar, AHA Scientist Development Grant Award (2014)
  • NIDDK Scholarship for Keystone Symposia (2008, 2011, and 2013)
  • Brown-Coxe Fellowship (2010)

Professional Associations

Reviewers for Diabetes, J Biol Chem, PLos ONE, Mol Metab, Mol Med, Endocrine, Endocrinology, Exp Clin Endocrinol Diabetes, AJP-Endocrinol Metab, etc.


Research Summary/Interests

The major research topic in the Ruan Lab is nutritional and hormonal regulation of metabolic homeostasis, with a particular focus on O-GlcNAc signaling in metabolic regulation. Current ongoing projects include: Novel secreted factors and neuronal circuits that control thermogenesis in brown and beige adipocytes; Mechanisms and functions of autophagy in metabolic homeostasis; Microbiota-host interactions in obesity and digestive diseases; Inflammation in obesity, diabetes, and inflammatory bowel disease.

Research Funding Grants

  • AHA Scientist Development Grant


  • Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. (2014). O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell. 159(2): 306-317.
  • Huang Z*, Ruan HB*, Xian L, Chen W, Jiang S, Song A, Wang Q, Shi P, Gu X, Gao X. (2014) The stem cell factor/Kit signaling pathway regulates mitochondrial function and energy expenditure. Nat Commun. 5:4282. (*, Equal contribution).
  • Ruan HB, Singh JP, Li MD, Wu J, Yang, X. (2013). Cracking the O-GlcNAc code in metabolism. Trends Endocrinol Metab. 24(6): 301-309.
  • Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR, Yang X. (2012). O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1? stability. Cell Metab. 16(2): 226-237.